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PDI consists of four domains ( a, b, b, a ), two of which ( a and a ) contain thioredoxin-related reactive CXXC motifs that facilitate disulfide exchange ( b and b domains are not catalytically active, but act as chaperones for substrate binding (Klappa et al., 1998)

GHK and its copper complexes penetrate the stratum corneum and can be delivered transdermally in creams, gels or skin patches [ 49 , 50 ]

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